What’s the best wager to make, looking at each of the 16 matchups on the NFL’s Week 3 schedule? Our favorite point-spread pick is Saints -3, but we have plenty more suggestions for you, which could lead to parlay possibilities, in this article.

Best Week 3 Spread Bets

Jump to Matchup:

Pick: Colts -1 vs. Bears

• Matchup: Chicago Bears at Indianapolis Colts
• Projected Winner & Margin: Colts by 2.8 points (Bet on this game at BetMGM)
• Spread: Colts -1
• Time: 1:00 PM ET
• Date: Sept. 22
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Steelers -1.5 vs. Chargers

• Matchup: Los Angeles Chargers at Pittsburgh Steelers
• Projected Winner & Margin: Steelers by 1.9 points (Bet on this game at BetMGM)
• Spread: Steelers -1.5
• Time: 1:00 PM ET
• Date: Sept. 22
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Cowboys +1.5 vs. Ravens

• Matchup: Baltimore Ravens at Dallas Cowboys
• Projected Winner & Margin: Ravens by 0.7 points (Bet on this game at BetMGM)
• Spread: Ravens -1.5
• Time: 4:25 PM ET
• Date: Sept. 22
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Vikings +2.5 vs. Texans

• Matchup: Houston Texans at Minnesota Vikings
• Projected Winner & Margin: Vikings by 5.1 points (Bet on this game at BetMGM)
• Spread: Texans -2.5
• Time: 1:00 PM ET
• Date: Sept. 22
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Saints -3 vs. Eagles

• Matchup: Philadelphia Eagles at New Orleans Saints
• Projected Winner & Margin: Saints by 23.3 points (Bet on this game at BetMGM)
• Spread: Saints -3
• Time: 1:00 PM ET
• Date: Sept. 22
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Make smart decisions. Use those stats when making your NFL picks and place your bet on BetMGM.

Best Week 3 Total Bets

Jump to Matchup:

Under 35.5 – Chargers vs. Steelers

• Matchup: Los Angeles Chargers at Pittsburgh Steelers
• Projected Total: 27.0 points (Bet on this game at BetMGM)
• Time: 1:00 PM ET
• Date: Sept. 22
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Over 48.5 – Ravens vs. Cowboys

• Matchup: Baltimore Ravens at Dallas Cowboys
• Projected Total: 52.3 points (Bet on this game at BetMGM)
• Time: 4:25 PM ET
• Date: Sept. 22
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Over 49.5 – Eagles vs. Saints

• Matchup: Philadelphia Eagles at New Orleans Saints
• Projected Total: 56.5 points (Bet on this game at BetMGM)
• Time: 1:00 PM ET
• Date: Sept. 22
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 46.5 – Chiefs vs. Falcons

• Matchup: Kansas City Chiefs at Atlanta Falcons
• Projected Total: 42.3 points (Bet on this game at BetMGM)
• Time: 8:20 PM ET
• Date: Sept. 22
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Over 41 – Panthers vs. Raiders

• Matchup: Carolina Panthers at Las Vegas Raiders
• Projected Total: 41.8 points (Bet on this game at BetMGM)
• Time: 4:05 PM ET
• Date: Sept. 22
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

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